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Rosner, Marsha

One or more keywords matched the following properties of Rosner, Marsha

Property	Value
keywords	Single Cell Analysis
keywords	Signal Transduction Pathways
overview	Cancer is the second leading cause of death but, unlike heart disease, it has been a difficult disease to effectively understand or treat. The reason relates to the complexity and heterogeneity of the disease. Most tumors have complicated origins and are driven by rare mutations. Furthermore, different tissues have distinct cancers, individual tissues have multiple cancer subtypes, and tumors are composed of cells that are both genetically and phenotypically diverse. Thus, every tumor is unique and dynamic. The cause of lethality in most solid tumors such as breast cancer is the metastatic dissemination of tumor cells throughout the body. Metastasis is characterized by many distinct properties that are driven by changing stresses in the tumor microenvironment. Underlying all of these events are subcellular signaling pathways within tumor and environmental cells that are ultimately responsible for driving cells to a tumorigenic state. The current focus of my laboratory is to understand fundamental signaling mechanisms leading to the generation of tumor cells and their progression to metastatic disease, particularly in triple-negative breast cancer that lacks targeted therapies. We use systems level approaches including activity-based proteomics, RNAseq, ChIPseq, and mass spectrometry as well as computational, molecular, biophysical, cellular and mouse model-based methodologies to identify and characterize key regulators of tumor growth and metastasis. As an additional tool, we have utilized a specific physiological suppressor of metastasis, Raf Kinase Inhibitory Protein (RKIP or PEBP1), and a downstream target of RKIP in cells, BACH1, to identify both molecular and cellular mediators of metastasis. Our recent studies have shown that regulators of metastasis control multiple processes within the tumor cell microenvironment including metabolism, redox state, extracellular matrix, and recruitment and programming of tumor-associated macrophages. These factors also direct extracellular vesicles (exosomes) secreted by tumor cells to reprogram other cells in the body toward a pro-metastatic phenotype. Correlating omic-generated data from these studies with clinical data from cancer patients led to the identification of novel signaling modules that we used to build gene signatures that predict the metastatic potential of a tumor. More recently, our studies have led us to potential therapeutic treatments based on the concept of targeting key regulators of tumorigenesis, mimicking the action of metastasis suppressors such as RKIP or reprogramming signaling networks in cells to sensitize tumors to therapeutic agents.

One or more keywords matched the following items that are connected to Rosner, Marsha

Item Type	Name
Concept	Carcinoma, Squamous Cell
Concept	Cell Fractionation
Concept	Cell Line, Transformed
Concept	Cell Count
Concept	Cell Differentiation
Concept	Cell Movement
Concept	Cell Nucleus
Concept	Carcinoma, Renal Cell
Concept	Cell Membrane
Concept	Cell Division
Concept	Cell Extracts
Concept	Clone Cells
Concept	Cell Transformation, Viral
Concept	Cell-Free System
Concept	Cell Cycle
Concept	Cell Transformation, Neoplastic
Concept	Cell Aggregation
Concept	Cell Compartmentation
Concept	Cell Fusion
Concept	Epithelial Cells
Concept	HeLa Cells
Concept	Hybrid Cells
Concept	Receptors, Cell Surface
Concept	Stem Cells
Concept	CHO Cells
Concept	Cell Culture Techniques
Concept	Tumor Cells, Cultured
Concept	PC12 Cells
Concept	3T3 Cells
Concept	Pyramidal Cells
Concept	Cell Proliferation
Concept	Intercellular Signaling Peptides and Proteins
Concept	Primary Cell Culture
Concept	NIH 3T3 Cells
Concept	COS Cells
Concept	Cell Growth Processes
Concept	Cell Cycle Proteins
Concept	Active Transport, Cell Nucleus
Concept	Shc Signaling Adaptor Proteins
Concept	HEK293 Cells
Concept	Vero Cells
Concept	Adaptor Proteins, Signal Transducing
Concept	Cell Death
Concept	Stromal Cells
Concept	MAP Kinase Signaling System
Concept	Extracellular Signal-Regulated MAP Kinases
Concept	Endothelial Cells
Concept	Cell Line, Tumor
Concept	Intracellular Signaling Peptides and Proteins
Concept	Cell Size
Concept	Cell Shape
Concept	Cell Line
Concept	Cell Survival
Concept	Cells, Cultured
Concept	Receptors, Antigen, T-Cell
Concept	Neoplastic Stem Cells
Concept	Signal Transduction
Academic Article	Mutations in a zinc-binding domain of human insulin-degrading enzyme eliminate catalytic activity but not insulin binding.
Academic Article	Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: roles for Ras and Src.
Academic Article	Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells.
Academic Article	Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation.
Academic Article	Src tyrosine kinase mediates stimulation of Raf-1 and mitogen-activated protein kinase by the tumor promoter thapsigargin.
Academic Article	Cloning and characterization of MST4, a novel Ste20-like kinase.
Academic Article	Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel.
Academic Article	Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth.
Academic Article	A novel mitogen-activated protein kinase is responsive to Raf and mediates growth factor specificity.
Academic Article	ERK7 is an autoactivated member of the MAPK family.
Academic Article	ERK8, a new member of the mitogen-activated protein kinase family.
Academic Article	Regulation of insulin degradation: expression of an evolutionarily conserved insulin-degrading enzyme increases degradation via an intracellular pathway.
Academic Article	Localization of the gene encoding insulin-degrading enzyme to human chromosome 10, bands q23----q25.
Academic Article	ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathway.
Academic Article	Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma.
Academic Article	Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1.
Academic Article	Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.
Academic Article	A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle.
Academic Article	Raf kinase inhibitory protein function is regulated via a flexible pocket and novel phosphorylation-dependent mechanism.
Academic Article	tRNA over-expression in breast cancer and functional consequences.
Academic Article	Innate immune and chemically triggered oxidative stress modifies translational fidelity.
Academic Article	A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
Academic Article	Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands.
Academic Article	Sodium as a mediator of non-phorbol tumor promoter action. Down-modulation of the epidermal growth factor receptor by palytoxin.
Academic Article	Raf kinase inhibitory protein (RKIP): a physiological regulator and future therapeutic target.
Academic Article	Identification of novel metastasis suppressor signaling pathways for breast cancer.
Academic Article	Anthrax edema factor potency depends on mode of cell entry.
Academic Article	Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line.
Academic Article	Structure-activity studies of the nonphorbol tumor promoter palytoxin in Swiss 3T3 cells.
Academic Article	Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme.
Academic Article	Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context.
Academic Article	Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer.
Academic Article	Histamine antagonizes serotonin and growth factor-induced mitogen-activated protein kinase activation in bovine tracheal smooth muscle cells.
Academic Article	Hydrogen peroxide stimulates mitogen-activated protein kinase in bovine tracheal myocytes: implications for human airway disease.
Academic Article	Functional analysis of conserved residues in the active site of insulin-degrading enzyme.
Academic Article	Conditional immortalization of neuronal cells from postmitotic cultures and adult CNS.
Academic Article	Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration.
Academic Article	Anti-tumor effects of an engineered "killer" transfer RNA.
Academic Article	Apoptosis induced by differentiation or serum deprivation in an immortalized central nervous system neuronal cell line.
Academic Article	The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis.
Academic Article	Effect of complementary pathway blockade on efficacy of combination enzastaurin and rapamycin.
Academic Article	A novel interplay between Rap1 and PKA regulates induction of angiogenesis in prostate cancer.
Academic Article	Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis.
Academic Article	Identification of zinc ligands of the insulin-degrading enzyme.
Academic Article	Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor.
Academic Article	Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expression.
Academic Article	Methylprednisolone ameliorates retinal photic injury in rats.
Academic Article	Palytoxin down-modulates the epidermal growth factor receptor through a sodium-dependent pathway.
Academic Article	Interactions between retroviruses and environmental carcinogens and their role in animal and human leukemogenesis.
Academic Article	Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor.
Academic Article	Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes.
Academic Article	An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity.
Academic Article	Phosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters.
Academic Article	Characterization of murine-specific leukemia virus receptor from L cells.
Academic Article	Regulation of epidermal growth factor receptor gene expression by retinoic acid and epidermal growth factor.
Academic Article	Basic and acidic fibroblast growth factors modulate the epidermal growth factor receptor by a protein kinase C-independent pathway.
Academic Article	Identification of a novel receptor in Drosophila for both epidermal growth factor and insulin.
Academic Article	Transforming growth factor-beta increases transcription of the genes encoding the epidermal growth factor receptor and fibronectin in normal rat kidney fibroblasts.
Academic Article	Thapsigargin, a novel promoter, phosphorylates the epidermal growth factor receptor at threonine 669.
Academic Article	Growth factors modify the epidermal growth factor receptor through multiple pathways.
Academic Article	Characterization of rodent epidermal growth factor receptor transcripts using a mouse genomic probe.
Academic Article	Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter.
Academic Article	Characterization of a Drosophila protein that binds both epidermal growth factor and insulin-related growth factors.
Academic Article	Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster.
Academic Article	Characterization of protein kinase C from normal and transformed cultured murine fibroblasts.
Academic Article	Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.
Academic Article	Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase.
Academic Article	Two independent growth factor-generated signals regulate c-fos and c-myc mRNA levels in Swiss 3T3 cells.
Academic Article	Basic fibroblast-like growth factor is present in the conditioned medium of simian sarcoma virus transformed NRK cells.
Academic Article	Relationship of GIX antigen expression to the glycosylation of murine leukemia virus glycoprotein.
Academic Article	WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis.
Academic Article	Activation of mitogen-activated protein kinase by epidermal growth factor in hippocampal neurons and neuronal cell lines.
Academic Article	Developmental regulation of an insulin-degrading enzyme from Drosophila melanogaster.
Academic Article	Growth state-dependent regulation of protein kinase C in normal and transformed murine cells.
Academic Article	Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium.
Academic Article	Adenovirus and protein kinase C have distinct molecular requirements for regulating epidermal growth factor receptor trafficking.
Academic Article	N-asparagine-linked oligosaccharides: biosynthesis of the lipid-linked oligosaccharides.
Academic Article	Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells.
Academic Article	Mitogen-activated protein kinase regulates the epidermal growth factor receptor through activation of a tyrosine phosphatase.
Academic Article	Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells.
Academic Article	Induction of epidermal growth factor receptor gene transcription by transforming growth factor beta 1: association with loss of protein binding to a negative regulatory element.
Academic Article	Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.
Academic Article	Different protein kinase C isoforms determine growth factor specificity in neuronal cells.
Academic Article	Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein.
Academic Article	Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.
Academic Article	Identification of an epidermal growth factor receptor transcriptional repressor.
Academic Article	Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons.
Academic Article	Role of threonine residues in regulation of the epidermal growth factor receptor by protein kinase C and mitogen-activated protein kinase.
Academic Article	Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C.
Academic Article	Proteins interacting with the tuberous sclerosis gene products.
Academic Article	Insulin gene expression in immortalized rat hippocampal and pheochromocytoma-12 cell lines.
Academic Article	Mutation of Di-leucine residues in the juxtamembrane region alters EGF receptor expression.
Academic Article	Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line.
Academic Article	Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.
Academic Article	CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders.
Academic Article	A proline- and glutamine-rich protein promotes apoptosis in neuronal cells.
Academic Article	Differential effect of cycloheximide on neuronal and glioma cells treated with chemotherapy and radiation.
Academic Article	Cytoplasmic/nuclear localization of tuberin in different cell lines.
Academic Article	Tuberous sclerosis gene products in proliferation control.
Academic Article	Role of cyclins in neuronal differentiation of immortalized hippocampal cells.
Academic Article	mTOR phosphorylated at S2448 binds to raptor and rictor.
Academic Article	Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme.
Academic Article	Evidence for cell cycle-dependent, rapamycin-resistant phosphorylation of ribosomal protein S6 at S240/244.
Academic Article	FGF induces a switch in death receptor pathways in neuronal cells.
Academic Article	Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression.
Academic Article	Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells.
Academic Article	Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta.
Academic Article	Tuberin negatively affects BCL-2's cell survival function.
Academic Article	Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR.
Academic Article	Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas.
Academic Article	Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor.
Academic Article	Nuclear/cytoplasmic localization of Akt activity in the cell cycle.
Academic Article	Tuberin, p27 and mTOR in different cells.
Academic Article	The TSC1 gene product, hamartin, negatively regulates cell proliferation.
Academic Article	Characterization of a cysteine proteinase inhibitor induced during neuronal cell differentiation.
Academic Article	Ras mediates cell survival by regulating tuberin.
Academic Article	MAP kinase meets mitosis: a role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation.
Academic Article	Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein.
Academic Article	p70 S6K1 nuclear localization depends on its mTOR-mediated phosphorylation at T389, but not on its kinase activity towards S6.
Academic Article	Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7.
Academic Article	Proliferation potential of human amniotic fluid stem cells differently responds to mercury and lead exposure.
Academic Article	Nonheritable cellular variability accelerates the evolutionary processes of cancer.
Academic Article	14-3-3 proteins are involved in the regulation of mammalian cell proliferation.
Academic Article	NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta.
Academic Article	Akt regulates nuclear/cytoplasmic localization of tuberin.
Academic Article	HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.
Academic Article	Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint.
Academic Article	Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues.
Academic Article	Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines.
Academic Article	CDKs as therapeutic targets for the human genetic disease tuberous sclerosis?
Academic Article	MicroRNA-regulated feed forward loop network.
Academic Article	Embryoid body formation of human amniotic fluid stem cells depends on mTOR.
Academic Article	MAP kinase regulation of the mitotic spindle checkpoint.
Academic Article	RKIP regulates MAP kinase signaling in cells with defective B-Raf activity.
Academic Article	Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells.
Academic Article	RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy.
Academic Article	An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin.
Academic Article	Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor.
Academic Article	Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation.
Academic Article	Cyclin D1 is required for S phase traversal in bovine tracheal myocytes.
Academic Article	Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways.
Academic Article	Tuberin activates the proapoptotic molecule BAD.
Academic Article	Different cytoplasmic/nuclear distribution of S6 protein phosphorylated at S240/244 and S235/236.
Academic Article	An integrated view of cyclin E function and regulation.
Academic Article	A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients.
Academic Article	RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2.
Academic Article	Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions.
Academic Article	Har Gobind Khorana 1922-2011.
Academic Article	Retraction: Oct-3 is a maternal factor required for the first mouse embryonic division.
Academic Article	Raf kinase inhibitory protein (RKIP) as a metastasis suppressor: regulation of signaling networks in cancer.
Academic Article	Noise-Driven Phenotypic Heterogeneity with Finite Correlation Time in Clonal Populations.
Academic Article	Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages.
Academic Article	Interaction of tRNA with MEK2 in pancreatic cancer cells.
Academic Article	Gene expression in local stroma reflects breast tumor states and predicts patient outcome.
Academic Article	Raf kinase inhibitor protein: lessons of a better way for ß-adrenergic receptor activation in the heart.
Award or Honor Receipt	Quantrell Award for Excellence in Undergraduate Teaching, (Cell Biology)
Academic Article	Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer.
Academic Article	Limited inhibition of multiple nodes in a driver network blocks metastasis.
Academic Article	Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses.
Academic Article	Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop.
Academic Article	SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1a/XBP1 ER stress pathway in human lung-derived cells.
Academic Article	SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells.
Concept	A549 Cells
Concept	MCF-7 Cells
Grant	Regulation of RKIP Function
Grant	Tumor-stromal interactions as targets of tumor metastasis suppressors
Grant	REGULATION OF PROTEIN KINASE C
Grant	Signaling Pathways in Neuronal Cells
Grant	CHARACTERIZATION OF A NOVEL MAP/ERK KINASE
Grant	Modulation of Head and Neck Cancer by Protein Kinase C
Grant	Role of Raf Kinase Inhibitory Protein in Prostate Cancer
Grant	Signaling Pathways in Neuronal Cells

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